PaCO2 is inversely related to alveolar ventilation, and is considered the main indicator of alveolar ventilation. This patient has a combination of hypoxemia and hypocapnia. The process most likely responsible for this patient’s condition is: Arterial blood gases show a Pa02 of 54 mmHg and a PaCO2 of 26 mmHg. He says he has never experienced symptoms like this before. Q NO 3: A 45-year-old male presents to the ER with severe dyspnea of recent onset. In contrast, restrictive lung diseases can cause reduced lung volumes and increased FEV1/FVC. Emphysema also tends to increase TLC and RV. On pulmonary function testing all COPD yields a decreased FEV1/FVC ratio. This FEV1% increase is the combined result of reduced FVC, decreased lung compliance, and increased elastic recoil.Ĭhronic obstructive pulmonary disease (COPD) in a heavy smoker may consist of both emphysema and chronic bronchitis and thus may present with both progressive exertional dyspnea (characteristic of emphysema) and frequent respiratory infections (characteristic of chronic bronchitis). FEV1/FVC may be increased above the normal value of approximately 80%. In restrictive lung disease, lung volumes - particularly TLC and EVC - are decreased due to reduced lung expansion. (Choice E) This PFT profile is characteristic of restrictive lung disease (e.g. Choice C is the only option with a decreased (FEV1%) and an increase in both TLC and RV. Emphysema also causes a decrease in EVC and an increase in both TLC and RV due to destruction of interalveolar walls, decrease in lung elastic recoil, and distal airspace enlargement. The hallmark of an obstructive PFT profile is decreased FEV1/FVC (FEV1%) due to expiratory airflow obstruction. Chronic bronchitis and emphysema have similar effects on FEV1/FVC during pulmonary function testing (PFT).
COPD encompasses chronic bronchitis and emphysema. This patient’s clinical picture is consistent with chronic obstructive pulmonary disease (COPD). Pulmonary function testing will most likely show which of the following patterns of findings (TLC total lung capacity FEV 1 forced expiratory volume in 1 second FVC forced vital capacity RV, residual volume)? Physical examination reveals diffusely decreased breath sounds, increased chest anteroposterior diameter, and decreased diaphragmatic excursion. For the past 30 years he has smoked 1 Ѕ packs of cigarettes a day. He has had four respiratory infections over the course of the past year. Q NO 2: A 65-year-old male presents to your office with exertional dyspnea. Rupture usually occurs 3 to 7 days after the onset of total ischemia, when coagulative necrosis, neutrophil infiltration, and enzymatic lysis of connective tissue have sufficiently weakened the infarcted myocardium.
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Rupture of the ventricular free wall as a consequence of an acute transmural Ml can cause tamponade. The triad of muffled heart sounds elevated jugular venous pressure and profound hypotension indicates pericardial tamponade. This would be unusual as a complication of Ml. (Choice E) Right-to-left shunting is seen in patients with Eisenmenger syndrome, a complication of certain congenital heart diseases. (Choice C) Left-to-right shunting would occur as a result of ventricular septal rupture. On physical examination, the heart sounds are muffled and the jugular venous pressure is elevated. Failure to relieve the obstruction will lead to death.Ĭlinically, these patients present with profound hypotension and shortness of breath. This leads to profound systemic hypotension and pulseless electrical activity. As the pressure increases in the pericardial cavity, venous return to the heart is reduced. This complication of transmural (ST-elevation) myocardial infarction generally occurs 3 to 7 days after the onset of total ischemia, when coagulative necrosis neutrophil infiltration and enzymatic lysis of connective tissue have substantially weakened the infarcted myocardium (mean 4-5 days range 1-10 days).įree wall rupture causes cardiac tamponade, which greatly limits ventricular filling during diastole. The gross autopsy specimen shows a ruptured left ventricular (LV) free wall. The patient most likely died from which of the following? The autopsy findings are pictured below (RV = right ventricle, LAD = left anterior descending coronary artery).
Q NO 1: A 62-year-old Caucasian female hospitalized with acute myocardial infarction dies suddenly on day four of her hospitalization.